Product image is for illustrative purposes only. Actual medication, packaging, and labeling may vary depending on the dispensing pharmacy.
Progesterone Capsule
Progesterone balances estrogen in hormone therapy and helps protect the uterine lining, making it a key part of many menopause treatment plans. This immediate-release capsule is prescribed after a provider review, with the quantity set by your prescription.
- Several delivery forms
- Thyroid support where indicated
- Ongoing monitoring
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How it works
Submit your free assessment
Step 1: Complete your medical assessment for review by a licensed medical provider. If appropriate, the provider will determine whether the treatment is right for you.
Get your plan and your order at home
Step 2: If approved, your provider selects a formulation, strength, and schedule and explains how to use it. Your order ships in plain, unbranded packaging.
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Step 3: Access your patient portal to communicate with your care team, ask questions, and get support throughout your treatment journey.
Progesterone Capsule
How Progesterone supports hormone balance
Progesterone IR is an immediate-release capsule containing progesterone alone, offered in several strengths, including 100 mg and 200 mg. It is a single-ingredient product. Hormonal changes affect every woman differently. Your provider reviews your symptoms, history, and goals before recommending whether hormone therapy fits and in what form.
Several delivery forms
Creams, capsules, patches, and a vaginal insert are available through our pharmacy network. Not every option is right for every patient.
Thyroid support where indicated
T3 and T3/T4 capsules are available when your provider determines they are appropriate for you.
Ongoing monitoring
Your provider follows up to check how you are responding and adjusts your plan as needed over time.
Provider-guided from start to finish
A licensed provider reviews your health history, checks for contraindications, sets an appropriate starting plan, and monitors your progress over time.
How to use it
Clear instructions for your prescribed formulation arrive with your first order.
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Your treatment is evaluated by qualified, licensed providers.
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Medication is prescribed only when clinically appropriate.
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Quality and ingredient standards
Made in the U.S.A.
Some treatments are compounded by licensed U.S. pharmacies in facilities registered with the FDA. Registration does not mean a compounded medication is an FDA-approved finished medication.
USP <797>
Sterile compounding standards.
Documented handling.
Every batch released to spec.
ISO Class 7
Cleanroom-grade air.
Filtered environments.
Tighter contamination control.
Clean ingredients, careful delivery
- No heavy metals
- No added dyes
- Licensed U.S. pharmacies
- Provider-prescribed
- Cold-chain protection
- Plain, unbranded packaging
- Serves all 50 states
- HSA and FSA eligible
Medication guide
What to know about Progesterone Capsule
General education to help you prepare for a conversation with a licensed provider. It is not a prescription or personal medical advice.
- Generic name
- Progesterone (micronized)
- Brand names
- Prometrium (100 and 200 mg capsules)
- Drug class
- Progestogen
- Form
- Immediate-release capsule
- Regulatory status
- Compounded, not FDA-approved
- FDA-approved use
- Prometrium: preventing endometrial hyperplasia in postmenopausal women taking estrogen; secondary amenorrhea.
Micronized progesterone capsules (Prometrium) are FDA-approved. A compounded immediate-release progesterone capsule is not FDA-approved, and its strength and absorption have not been reviewed by FDA.
Compounded medications are not FDA-approved. FDA does not review them for safety, effectiveness or quality before they are dispensed. A compounded preparation can differ from approved products in strength, ingredients, dosage form and how it is absorbed, so it should not be assumed to work the same way as an approved medication. Compounding is meant for patients whose needs cannot be met by an FDA-approved drug.
Overview
Progesterone protects the uterine lining in women with a uterus who take estrogen, and is part of many menopause hormone regimens.
Who may be evaluated for it
- Women with a uterus who are taking systemic estrogen.
- Women with certain menstrual irregularities, as assessed by a provider.
Who may not be a good fit
- Women with unexplained vaginal bleeding, breast cancer, a past blood clot or stroke, or active liver disease.
- Anyone with a peanut allergy should check: Prometrium contains peanut oil; compounded capsules may differ.
How it works
Progesterone counterbalances estrogen’s growth effect on the uterine lining, which prevents the lining from overgrowing and lowers endometrial cancer risk. It also has a calming effect in the brain, which is why it can cause drowsiness.
Potential benefits and realistic timelines
What the evidence supports
- Taken with estrogen, it protects against endometrial hyperplasia.
Early or limited research
- Some studies suggest it may help sleep in menopausal women.
Not established
- That compounded progesterone protects the uterus as reliably as Prometrium. Topical progesterone creams have not been shown to protect the uterus.
- First cyclesIrregular spotting is common in the first months of combined therapy.
- About 3 to 6 monthsBleeding patterns usually settle; providers reassess.
Results vary from person to person. Your provider decides whether and how long to continue.
How it’s used
- Usually taken at bedtime because it can cause drowsiness or dizziness.
- Taken either daily or for 12 or more days each month, depending on your regimen.
If you miss a dose
Take it when you remember the same evening. If it is already the next day, skip it. Do not double up.
Storage and handling
Room temperature, away from moisture and light.
Your prescription label and provider instructions always take priority over this general information. Do not change your dose or stop without talking to your provider.
Side effects and safety
More common, usually manageable
- Drowsiness or dizziness
- Breast tenderness
- Bloating
- Mood changes
- Spotting
Less common but serious
- Blood clots and stroke (combined estrogen-progestin therapy)
- A small increase in breast cancer risk with long-term combined therapy
Get medical help right away
- Sudden chest pain, shortness of breath or coughing up blood.
- Pain, swelling or warmth in one leg.
- Sudden severe headache, vision loss, weakness or trouble speaking.
- Unexpected vaginal bleeding after menopause.
- A new breast lump.
Call 911 or go to the nearest emergency room for chest pain, trouble breathing, swelling of the face or throat, fainting, or signs of a stroke (sudden weakness, numbness, trouble speaking or seeing).
Pregnancy, breastfeeding and fertility
Not a contraceptive. Tell your provider if you might be pregnant.
Interactions and combinations
Known interactions
- Sedatives, sleep medicines and alcohol can add to drowsiness.
- Seizure medicines and rifampin can lower progesterone levels.
Related treatments and options
Listed for education, not as a recommendation to combine. Any combination needs your provider’s approval.
- Estradiol PatchSupported by evidence
Standard combination for women with a uterus.
- Estradiol CapsulesSupported by evidence
Standard combination for women with a uterus.
Already contains progesterone; do not double up.
Monitoring and follow-up
- A review of your symptoms, personal and family history of breast cancer, clots, heart disease and stroke, and your blood pressure.
- Up-to-date mammogram and cervical screening as recommended for your age.
- A follow-up visit within about 3 months of starting, then at least yearly to reassess dose and whether to continue.
- Any unexpected vaginal bleeding is evaluated promptly.
- Routine hormone blood levels are generally not recommended to guide menopause therapy, per The Menopause Society.
Lab tests and follow-up visits are not included in the medication price unless your plan says so. Your provider will tell you what is needed.
Alternatives to discuss
- BIEST (20:80) / Progesterone IR
Compounded capsule that combines estrogen and progesterone.
- Prometrium (brand)
The FDA-approved micronized progesterone.
- Levonorgestrel IUD
An alternative way to protect the uterus, placed by a clinician (off-label for this use).
Lab tested medications for quality and potency.
Every medication ships from a licensed U.S. pharmacy in our network, delivered straight to your door.
Third party quality control testing
Compounded in U.S. pharmacies
Dosage, Schedule & Supply
- Dosage
- Strengths include 100 mg and 200 mg. Your provider selects the strength.
- Schedule
- Determined by your prescribing provider.
- Supply
- Quantity set by your prescription.
- Estimated Supply Duration
- Varies based on the quantity and schedule on your prescription.
Supply duration is an estimate based on the prescribed treatment plan. Actual duration may vary depending on dosage, frequency of use, and medication expiration.
Treatment information is for educational purposes. Your licensed healthcare provider will determine the appropriate dosage and schedule. Always follow your prescription instructions.
Frequently Asked Questions
Why take it at night?
Progesterone can make you drowsy or dizzy, so bedtime dosing is usually recommended.
Does progesterone cream protect the uterus?
Topical progesterone creams have not been shown to protect the uterine lining. Oral micronized progesterone has.
Is spotting normal?
Irregular spotting is common in the first months. Report heavy, persistent or new bleeding after it has settled.
Do I need a prescription?
Yes. After your free consultation, a licensed provider reviews your intake, symptoms, and health history to decide what’s appropriate for you.
Is every formulation appropriate for me?
No. Your provider selects a formulation based on your individual symptoms, history, and goals, not every option listed is appropriate for every patient.
Is this available in my state?
Availability varies by formulation and state. Your provider will confirm what can be prescribed and shipped to you during your consultation.
Can I use my HSA or FSA?
Yes. Medura accepts HSA and FSA cards at checkout, and we can provide documentation for reimbursement if you need it.
What happens after I request treatment through Medura?
You complete an online assessment about your health history, current medications and goals. A licensed provider reviews it and decides whether a prescription is appropriate. Completing the assessment does not guarantee a prescription. If one is written, a licensed pharmacy prepares and ships it, and your provider can adjust or stop treatment as needed. If lab work is needed, your provider will tell you; it may be ordered and billed separately.
What to expect and possible side effects
- 1
Start with a consultation
A licensed provider reviews your intake, symptoms, and health history to determine whether hormone therapy is appropriate and which formulation may fit.
- 2
A plan matched to you
If approved, your provider selects a formulation, strength, and schedule, and explains how to use it.
- 3
Ongoing monitoring
Your provider follows up to check how you are responding and adjusts your plan as needed over time.
Questions to ask your provider
- 1.Should I take it daily or cyclically?
- 2.Is a compounded capsule appropriate, or should I use Prometrium?
- 3.What bleeding pattern should I expect?
- 4.Do I have a peanut allergy concern?
References
- Prometrium (progesterone capsules) prescribing information (DailyMed)(opens in a new tab)
- The 2022 Hormone Therapy Position Statement of The North American Menopause Society(opens in a new tab)
- FDA-approved labeling updates for menopausal hormone therapy boxed warnings (FDA, Feb 12, 2026)
- Menopause (MedlinePlus)(opens in a new tab)
- Compounding and the FDA: Questions and Answers (FDA)(opens in a new tab)
Sources last checked October 17, 2026. This page is for general education and does not replace advice from a licensed provider. Treatment requires a clinical evaluation, and a prescription is written only if a provider decides it is appropriate. Individual results vary.
Related Products & Treatments
Explore other options that may support your goals.
BIEST/Progesterone CapsuleProgesterone combined with BIEST in one capsule. Helps relieve menopause symptoms such as hot flashes and night sweats, with progesterone for balance.View details for BIEST/Progesterone Capsule
Estradiol CapsuleEstradiol, a different hormone, in capsules. Helps relieve menopause symptoms such as hot flashes and night sweats.View details for Estradiol Capsule
BIEST CreamAn estriol and estradiol topical cream. Helps relieve menopause symptoms such as hot flashes and night sweats.View details for BIEST Cream
DHEA CreamA compounded DHEA cream at 50–100 mg/mL in a 30 g presentation. Helps support low DHEA levels, and may ease vaginal dryness and low libido.View details for DHEA Cream
Estradiol PatchA transdermal estradiol patch at 0.025–0.1 mg/day, 8-pack. Helps relieve menopause symptoms such as hot flashes and night sweats.View details for Estradiol Patch
Estradiol Vaginal InsertA 10 mcg estradiol vaginal insert. Helps relieve vaginal dryness and discomfort during menopause.View details for Estradiol Vaginal Insert
Liothyronine T3 SR CapsuleA dye-free, sustained-release liothyronine (T3) capsule at 5–26 mcg. Helps with symptoms of low thyroid function such as fatigue, feeling cold and weight gain.View details for Liothyronine T3 SR Capsule
T3/T4 CapsuleA combination thyroid capsule containing T3 and T4. Helps with symptoms of low thyroid function such as fatigue, feeling cold and weight gain.View details for T3/T4 Capsule
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