Medura DHEA Cream pump bottle in premium metallic navy packaging

Product image is for illustrative purposes only. Actual medication, packaging, and labeling may vary depending on the dispensing pharmacy.

Women's HRT

DHEA Cream

DHEA is a hormone your body naturally makes less of with age, and this compounded cream offers a topical way to use it. Its benefits depend on why it's prescribed and the evidence is mixed, so a provider reviews whether it's appropriate. Supplied as a 30 g container.

  • Several delivery forms
  • Thyroid support where indicated
  • Ongoing monitoring

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  • Your Prescription MedicationYour prescribed medication is priced as listed on its treatment page, with no additional medication markup at checkout. Injectable treatments also include essential supplies at no extra cost: alcohol prep pads, gauze pads, syringes, drawing and injection needles, plus clear administration instructions.
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  • Temperature-Controlled PackagingCold-pack packaging is included when your medication requires it.
  • One Transparent Price. Everything Included.The price displayed isn't just for your medication. It also covers the required initial consultation with a licensed doctor, eligible expedited shipping, supplies, and temperature-controlled packaging when needed. While each of these services carries its own cost, we've bundled them into one reasonable, upfront price.

How it works

  1. Submit your free assessment

    Step 1: Complete your medical assessment for review by a licensed medical provider. If appropriate, the provider will determine whether the treatment is right for you.

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  2. Get your plan and your order at home

    Step 2: If approved, your provider selects a formulation, strength, and schedule and explains how to use it. Your order ships in plain, unbranded packaging.

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  3. Receive 24/7 Support and Ongoing Care

    Step 3: Access your patient portal to communicate with your care team, ask questions, and get support throughout your treatment journey.

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DHEA Cream

How DHEA supports hormone balance

DHEA Cream is a compounded topical cream containing dehydroepiandrosterone (DHEA). It is offered at 50–100 mg/mL in a 30 g presentation, with the strength set on your prescription. Hormonal changes affect every woman differently. Your provider reviews your symptoms, history, and goals before recommending whether hormone therapy fits and in what form.

  • Several delivery forms

    Creams, capsules, patches, and a vaginal insert are available through our pharmacy network. Not every option is right for every patient.

  • Thyroid support where indicated

    T3 and T3/T4 capsules are available when your provider determines they are appropriate for you.

  • Ongoing monitoring

    Your provider follows up to check how you are responding and adjusts your plan as needed over time.

  • Provider-guided from start to finish

    A licensed provider reviews your health history, checks for contraindications, sets an appropriate starting plan, and monitors your progress over time.

  • How to use it

    Clear instructions for your prescribed formulation arrive with your first order.

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Your health deserves more than a one-size-fits-all approach.

Medura connects you with licensed medical professionals who take the time to review your health history, evaluate your individual needs, and determine which treatments may be right for you.

We believe quality healthcare should come with professional oversight, personalized attention, and honest, transparent medication pricing.

No unnecessary medication markups. No confusing treatment pricing. Just a more straightforward approach to getting the care you deserve.

  • Licensed Medical Professionals

    Your treatment is evaluated by qualified, licensed providers.

  • Personalized Medical Evaluations

    Recommendations are based on your individual health needs.

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    Medication is prescribed only when clinically appropriate.

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Quality and ingredient standards

Made in the U.S.A.

Some treatments are compounded by licensed U.S. pharmacies in facilities registered with the FDA. Registration does not mean a compounded medication is an FDA-approved finished medication.

  • USP <797>

    Sterile compounding standards.

    Documented handling.

    Every batch released to spec.

  • ISO Class 7

    Cleanroom-grade air.

    Filtered environments.

    Tighter contamination control.

Clean ingredients, careful delivery

  • No heavy metals
  • No added dyes
  • Licensed U.S. pharmacies
  • Provider-prescribed
  • Cold-chain protection
  • Plain, unbranded packaging
  • Serves all 50 states
  • HSA and FSA eligible

Medication guide

What to know about DHEA Cream

General education to help you prepare for a conversation with a licensed provider. It is not a prescription or personal medical advice.

Generic name
Dehydroepiandrosterone (DHEA)
Brand names
Intrarosa (FDA-approved vaginal insert, prasterone)
Drug class
Adrenal steroid hormone (precursor to estrogens and androgens)
Form
Cream
Regulatory status
Compounded, not FDA-approved
FDA-approved use
Intrarosa (vaginal prasterone): moderate to severe pain during sex due to menopause.

DHEA cream is a compounded preparation and is not FDA-approved. The only FDA-approved DHEA product is a 6.5 mg vaginal insert (prasterone, Intrarosa) for pain with sex due to menopause. Oral DHEA is also sold as a dietary supplement, which FDA does not review for effectiveness.

Compounded medications are not FDA-approved. FDA does not review them for safety, effectiveness or quality before they are dispensed. A compounded preparation can differ from approved products in strength, ingredients, dosage form and how it is absorbed, so it should not be assumed to work the same way as an approved medication. Compounding is meant for patients whose needs cannot be met by an FDA-approved drug.

Overview

DHEA cream is used by some providers for vaginal dryness or low sexual desire after menopause. The strongest evidence is for the approved vaginal insert.

Who may be evaluated for it

  • Postmenopausal women with vaginal dryness or pain with sex.

Who may not be a good fit

  • Women with a history of breast or other hormone-sensitive cancer.
  • Anyone with unexplained vaginal bleeding.
  • Women who are pregnant or breastfeeding.

How it works

DHEA is a hormone the body converts into small amounts of estrogen and testosterone inside tissues. Used vaginally, it is converted locally, which helps restore vaginal tissue.

Potential benefits and realistic timelines

What the evidence supports

  • Vaginal prasterone (the approved insert) improves pain with sex due to menopause.

Early or limited research

  • Small studies suggest possible effects on sexual function.

Not established

  • That compounded DHEA cream gives the same result as the approved insert.
  • Anti-aging, energy or weight benefits.
  1. About 8 to 12 weeksStudies of the vaginal insert assessed benefit after about 12 weeks.

Results vary from person to person. Your provider decides whether and how long to continue.

How it’s used

  • Apply as directed on your pharmacy label, either vaginally or to the skin.
  • Wash hands after use.

If you miss a dose

Apply when you remember; do not double up.

Storage and handling

Room temperature in the closed container.

Your prescription label and provider instructions always take priority over this general information. Do not change your dose or stop without talking to your provider.

Side effects and safety

More common, usually manageable

  • Vaginal discharge (with vaginal use)
  • Acne or oily skin
  • Unwanted hair growth

Less common but serious

  • Hormone effects on breast or uterine tissue are not well studied for compounded creams.

Get medical help right away

  • Vaginal bleeding after menopause
  • A new breast lump

Call 911 or go to the nearest emergency room for chest pain, trouble breathing, swelling of the face or throat, fainting, or signs of a stroke (sudden weakness, numbness, trouble speaking or seeing).

Pregnancy, breastfeeding and fertility

Not for use during pregnancy or breastfeeding.

Interactions and combinations

Known interactions

  • Other hormone therapies (estrogen, testosterone) can add to its effect.

Related treatments and options

Listed for education, not as a recommendation to combine. Any combination needs your provider’s approval.

Monitoring and follow-up

  • Symptom review after about 3 months.
  • Prompt evaluation of any vaginal bleeding.

Lab tests and follow-up visits are not included in the medication price unless your plan says so. Your provider will tell you what is needed.

Alternatives to discuss

  • Estradiol Vaginal Insert

    FDA-approved local estrogen for vaginal symptoms.

  • Vaginal moisturizers and lubricants

    Non-prescription first-line options.

Potency TestTested
Sterility TestTested
Endotoxin TestTested
pH TestTested

Lab tested medications for quality and potency.

Every medication ships from a licensed U.S. pharmacy in our network, delivered straight to your door.

  • Third party quality control testing

  • Compounded in U.S. pharmacies

Dosage, Schedule & Supply

Dosage
50 to 100 mg/mL concentration.
Schedule
Determined by your prescribing provider.
Supply
30 g.
Estimated Supply Duration
Varies based on the amount applied and how often it is used.

Supply duration is an estimate based on the prescribed treatment plan. Actual duration may vary depending on dosage, frequency of use, and medication expiration.

Treatment information is for educational purposes. Your licensed healthcare provider will determine the appropriate dosage and schedule. Always follow your prescription instructions.

Frequently Asked Questions

Is DHEA cream the same as Intrarosa?

No. Intrarosa is an FDA-approved vaginal insert with a fixed dose. DHEA cream is compounded and not FDA-approved.

Will DHEA help with energy or aging?

These claims are not supported by good evidence.

Do I need a prescription?

Yes. After your free consultation, a licensed provider reviews your intake, symptoms, and health history to decide what’s appropriate for you.

Is every formulation appropriate for me?

No. Your provider selects a formulation based on your individual symptoms, history, and goals, not every option listed is appropriate for every patient.

Is this available in my state?

Availability varies by formulation and state. Your provider will confirm what can be prescribed and shipped to you during your consultation.

Can I use my HSA or FSA?

Yes. Medura accepts HSA and FSA cards at checkout, and we can provide documentation for reimbursement if you need it.

What happens after I request treatment through Medura?

You complete an online assessment about your health history, current medications and goals. A licensed provider reviews it and decides whether a prescription is appropriate. Completing the assessment does not guarantee a prescription. If one is written, a licensed pharmacy prepares and ships it, and your provider can adjust or stop treatment as needed. If lab work is needed, your provider will tell you; it may be ordered and billed separately.

What to expect and possible side effects

  1. 1

    Start with a consultation

    A licensed provider reviews your intake, symptoms, and health history to determine whether hormone therapy is appropriate and which formulation may fit.

  2. 2

    A plan matched to you

    If approved, your provider selects a formulation, strength, and schedule, and explains how to use it.

  3. 3

    Ongoing monitoring

    Your provider follows up to check how you are responding and adjusts your plan as needed over time.

Questions to ask your provider

  1. 1.Would the FDA-approved insert or vaginal estrogen be better for me?
  2. 2.Should this be applied vaginally or to the skin?
  3. 3.What side effects should I watch for?

References

Sources last checked October 17, 2026. This page is for general education and does not replace advice from a licensed provider. Treatment requires a clinical evaluation, and a prescription is written only if a provider decides it is appropriate. Individual results vary.

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Explore other options that may support your goals.

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