Medura Estradiol Vaginal Insert box in premium metallic navy packaging

Product image is for illustrative purposes only. Actual medication, packaging, and labeling may vary depending on the dispensing pharmacy.

Women's HRT

Estradiol Vaginal Insert

Estradiol vaginal inserts deliver low-dose estrogen right where it's needed, easing dryness, discomfort and other vaginal and urinary symptoms of menopause. Because the effect is mostly local, it can be an option even for women who don't need full-body hormone therapy. The quantity is set by your prescription.

  • Several delivery forms
  • Thyroid support where indicated
  • Ongoing monitoring

Save 10% on Your First Prescription Order

New prescription customers save 10% with code MEDURA10. Enter your code during checkout after your assessment.

Answer to see the price

Which one of the following best describes your preferences today?

Your Treatment. Everything Included.

Know what's included in your treatment, from your initial virtual consultation to prescription delivery.

  • Your Prescription MedicationYour prescribed medication is priced as listed on its treatment page, with no additional medication markup at checkout. Injectable treatments also include essential supplies at no extra cost: alcohol prep pads, gauze pads, syringes, drawing and injection needles, plus clear administration instructions.
  • Initial Virtual ConsultationYour required initial virtual consultation is included in the treatment price. Refills during its validity period are not charged that fee again.
  • Licensed Provider ReviewA licensed provider reviews your information to decide if treatment is appropriate. An assessment does not guarantee a prescription.
  • Unlimited Doctor AccessIncludes unlimited doctor access in-between subscriptions.
  • Free Expedited Prescription ShippingIncluded with eligible prescription orders, shipped in discreet, unbranded packaging.
  • Temperature-Controlled PackagingCold-pack packaging is included when your medication requires it.
  • One Transparent Price. Everything Included.The price displayed isn't just for your medication. It also covers the required initial consultation with a licensed doctor, eligible expedited shipping, supplies, and temperature-controlled packaging when needed. While each of these services carries its own cost, we've bundled them into one reasonable, upfront price.

How it works

  1. Submit your free assessment

    Step 1: Complete your medical assessment for review by a licensed medical provider. If appropriate, the provider will determine whether the treatment is right for you.

    Hands holding a phone that shows a short health questionnaire

  2. Get your plan and your order at home

    Step 2: If approved, your provider selects a formulation, strength, and schedule and explains how to use it. Your order ships in plain, unbranded packaging.

    A sealed, plain shipping box

  3. Receive 24/7 Support and Ongoing Care

    Step 3: Access your patient portal to communicate with your care team, ask questions, and get support throughout your treatment journey.

    A smiling woman reading a message on her phone
An older woman with short white hair enjoying tea in a warm kitchen

Estradiol Vaginal Insert

How Estradiol Vaginal Insert supports hormone balance

The Estradiol Vaginal Insert is a 10 mcg estradiol insert placed vaginally. It is a localized form of estradiol, distinct from the oral capsule and the transdermal patch. Hormonal changes affect every woman differently. Your provider reviews your symptoms, history, and goals before recommending whether hormone therapy fits and in what form.

  • Several delivery forms

    Creams, capsules, patches, and a vaginal insert are available through our pharmacy network. Not every option is right for every patient.

  • Thyroid support where indicated

    T3 and T3/T4 capsules are available when your provider determines they are appropriate for you.

  • Ongoing monitoring

    Your provider follows up to check how you are responding and adjusts your plan as needed over time.

  • Provider-guided from start to finish

    A licensed provider reviews your health history, checks for contraindications, sets an appropriate starting plan, and monitors your progress over time.

  • How to use it

    Clear instructions for your prescribed formulation arrive with your first order.

Start my free assessment
A physician smiling and listening to a patient during a consultation

Real Medical Professionals. Personalized Care. Transparent Pricing.

Your health deserves more than a one-size-fits-all approach.

Medura connects you with licensed medical professionals who take the time to review your health history, evaluate your individual needs, and determine which treatments may be right for you.

We believe quality healthcare should come with professional oversight, personalized attention, and honest, transparent medication pricing.

No unnecessary medication markups. No confusing treatment pricing. Just a more straightforward approach to getting the care you deserve.

  • Licensed Medical Professionals

    Your treatment is evaluated by qualified, licensed providers.

  • Personalized Medical Evaluations

    Recommendations are based on your individual health needs.

  • Provider-Approved Prescriptions

    Medication is prescribed only when clinically appropriate.

  • Transparent Medication Pricing

    Know the medication price before moving forward.

Start My Free Assessment

Connect with a licensed medical professional and discover whether treatment is right for you. Prescriptions require a medical evaluation and provider approval.

Quality and ingredient standards

Made in the U.S.A.

Some treatments are compounded by licensed U.S. pharmacies in facilities registered with the FDA. Registration does not mean a compounded medication is an FDA-approved finished medication.

  • USP <797>

    Sterile compounding standards.

    Documented handling.

    Every batch released to spec.

  • ISO Class 7

    Cleanroom-grade air.

    Filtered environments.

    Tighter contamination control.

Clean ingredients, careful delivery

  • No heavy metals
  • No added dyes
  • Licensed U.S. pharmacies
  • Provider-prescribed
  • Cold-chain protection
  • Plain, unbranded packaging
  • Serves all 50 states
  • HSA and FSA eligible

Medication guide

What to know about Estradiol Vaginal Insert

General education to help you prepare for a conversation with a licensed provider. It is not a prescription or personal medical advice.

Generic name
Estradiol
Brand names
Vagifem, Yuvafem (10 mcg inserts)
Drug class
Estrogen
Form
Vaginal insert (10 mcg)
Regulatory status
FDA-approved medication
FDA-approved use
Atrophic vaginitis due to menopause.

Estradiol 10 mcg vaginal inserts are FDA-approved to treat vaginal dryness and atrophy due to menopause. Very little estradiol reaches the bloodstream.

Overview

Low-dose local estrogen to relieve vaginal dryness, irritation and pain with sex caused by menopause (genitourinary syndrome of menopause).

Who may be evaluated for it

  • Postmenopausal women with vaginal dryness, burning, irritation or pain with sex.
  • Some women with recurrent urinary tract infections after menopause.

Who may not be a good fit

  • Anyone with unexplained vaginal bleeding.
  • Women with a history of breast cancer need a discussion with their oncologist first.
  • Women who are pregnant.

How it works

Estradiol restores thickness, moisture and elasticity of vaginal and urinary tissue that thins when estrogen falls after menopause. At this low dose, effects stay mostly local.

Potential benefits and realistic timelines

What the evidence supports

  • Improves vaginal dryness, irritation and pain with sex.
  • May reduce recurrent urinary tract infections after menopause.

Not established

  • Relief of hot flashes (the dose is too low).
  • Bone protection.
  1. 2 to 4 weeksSome improvement in dryness is often felt.
  2. 8 to 12 weeksFull benefit is usually reached.

Results vary from person to person. Your provider decides whether and how long to continue.

How it’s used

The FDA label for 10 mcg inserts: one insert daily for 2 weeks, then one insert twice weekly. Your provider confirms your schedule.

  • Insert into the vagina with the applicator, ideally at bedtime.
  • Wash your hands before and after.

If you miss a dose

Insert it as soon as you remember, then continue your usual schedule. Do not use two at once.

Storage and handling

Room temperature in the original packaging.

Your prescription label and provider instructions always take priority over this general information. Do not change your dose or stop without talking to your provider.

Side effects and safety

More common, usually manageable

  • Vaginal discharge or itching
  • Mild spotting
  • Headache

Less common but serious

  • Because little is absorbed, systemic risks are much lower than with pills or patches, but labels still carry estrogen class warnings.

Get medical help right away

  • Any vaginal bleeding after menopause
  • Sudden chest pain, leg swelling, or stroke symptoms

Call 911 or go to the nearest emergency room for chest pain, trouble breathing, swelling of the face or throat, fainting, or signs of a stroke (sudden weakness, numbness, trouble speaking or seeing).

Pregnancy, breastfeeding and fertility

Not for use during pregnancy.

Interactions and combinations

Known interactions

  • Few clinically important interactions at this low dose. Tell your provider about all hormone products you use.

Related treatments and options

Listed for education, not as a recommendation to combine. Any combination needs your provider’s approval.

  • Systemic estrogen (patch or capsules)Only with provider supervision

    Sometimes added if vaginal symptoms persist on systemic therapy.

  • Vaginal moisturizersSupported by evidence

    Can be used alongside.

Monitoring and follow-up

  • Symptom review after about 3 months.
  • Prompt evaluation of any vaginal bleeding.
  • A progestogen is generally not needed with low-dose vaginal estrogen.

Lab tests and follow-up visits are not included in the medication price unless your plan says so. Your provider will tell you what is needed.

Alternatives to discuss

  • DHEA Cream

    A compounded DHEA cream. (An FDA-approved vaginal DHEA insert, prasterone, exists.)

  • Vaginal moisturizers and lubricants

    Non-prescription first-line options for mild dryness.

  • Estradiol Patch

    Systemic option if hot flashes are also a concern.

Potency TestTested
Sterility TestTested
Endotoxin TestTested
pH TestTested

Lab tested medications for quality and potency.

Every medication ships from a licensed U.S. pharmacy in our network, delivered straight to your door.

  • Third party quality control testing

  • Compounded in U.S. pharmacies

Dosage, Schedule & Supply

Dosage
10 mcg.
Schedule
Determined by your prescribing provider.
Supply
Quantity set by your prescription.
Estimated Supply Duration
Varies based on the quantity and schedule on your prescription.

Supply duration is an estimate based on the prescribed treatment plan. Actual duration may vary depending on dosage, frequency of use, and medication expiration.

Treatment information is for educational purposes. Your licensed healthcare provider will determine the appropriate dosage and schedule. Always follow your prescription instructions.

Frequently Asked Questions

Will this help hot flashes?

No. The dose is designed to act locally in vaginal tissue and does not treat hot flashes.

Do I need progesterone with it?

Generally no, at this low dose. Report any bleeding to your provider.

How soon will I feel better?

Often within a few weeks, with full benefit around 8 to 12 weeks.

Do I need a prescription?

Yes. After your free consultation, a licensed provider reviews your intake, symptoms, and health history to decide what’s appropriate for you.

Is every formulation appropriate for me?

No. Your provider selects a formulation based on your individual symptoms, history, and goals, not every option listed is appropriate for every patient.

Is this available in my state?

Availability varies by formulation and state. Your provider will confirm what can be prescribed and shipped to you during your consultation.

Can I use my HSA or FSA?

Yes. Medura accepts HSA and FSA cards at checkout, and we can provide documentation for reimbursement if you need it.

What happens after I request treatment through Medura?

You complete an online assessment about your health history, current medications and goals. A licensed provider reviews it and decides whether a prescription is appropriate. Completing the assessment does not guarantee a prescription. If one is written, a licensed pharmacy prepares and ships it, and your provider can adjust or stop treatment as needed. If lab work is needed, your provider will tell you; it may be ordered and billed separately.

What to expect and possible side effects

  1. 1

    Start with a consultation

    A licensed provider reviews your intake, symptoms, and health history to determine whether hormone therapy is appropriate and which formulation may fit.

  2. 2

    A plan matched to you

    If approved, your provider selects a formulation, strength, and schedule, and explains how to use it.

  3. 3

    Ongoing monitoring

    Your provider follows up to check how you are responding and adjusts your plan as needed over time.

Questions to ask your provider

  1. 1.Is low-dose vaginal estrogen safe with my history?
  2. 2.How long should I use the daily starting phase?
  3. 3.What should I do if I notice bleeding?
  4. 4.Would a non-hormonal option work for me?

References

Sources last checked October 17, 2026. This page is for general education and does not replace advice from a licensed provider. Treatment requires a clinical evaluation, and a prescription is written only if a provider decides it is appropriate. Individual results vary.

Related Products & Treatments

Explore other options that may support your goals.

Not Sure Where to Start?

We're here to make things simple. Book a free 15-minute Google Meet consultation with our team to get help navigating Medura, understanding the assessment process, pricing, and next steps.

Book a Free 15-Minute Consultation

This is a customer support session on Google Meet, not a medical consultation. You will not receive medical care, medical advice, or treatment recommendations, and you will not be speaking with a licensed physician. All medical evaluations and treatment decisions are handled separately by licensed healthcare providers.

Map of the United States with every state highlighted

Health and wellness, nationwide.

From everyday wellness essentials to personalized medical treatments, Medura makes it easier to take control of your health, wherever you are in the U.S.

Explore personalized treatment guidance
Health quiz

Not sure where to start?

Answer 10 quick questions to explore Medura products and treatment options that may align with your health goals.

Start Quiz

Educational only. Not medical advice.