Medura Sermorelin Troche jar in premium metallic navy packaging

Product image is for illustrative purposes only. Actual medication, packaging, and labeling may vary depending on the dispensing pharmacy.

Longevity & Anti-Aging

Sermorelin Troche

This sermorelin troche dissolves slowly in the mouth, offering a needle-free way to take the growth-hormone-releasing peptide. Oral absorption of peptides is less established than injection, so this compounded option is prescribed only after provider review. Supplied as 90 or 96 troches, depending on the formulation.

  • Works with your body, not around it
  • Sleep, recovery, and lean composition
  • Provider-guided from start to finish

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  • Your Prescription MedicationYour prescribed medication is priced as listed on its treatment page, with no additional medication markup at checkout. Injectable treatments also include essential supplies at no extra cost: alcohol prep pads, gauze pads, syringes, drawing and injection needles, plus clear administration instructions.
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How it works

  1. Submit your free assessment

    Step 1: Complete your medical assessment for review by a licensed medical provider. If appropriate, the provider will determine whether the treatment is right for you.

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  2. Get your plan and your order at home

    Step 2: Once approved, your provider sets a schedule that fits your routine. Your order ships in plain, unbranded packaging. Temperature-sensitive items ship with cold-chain protection.

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  3. Receive 24/7 Support and Ongoing Care

    Step 3: Access your patient portal to communicate with your care team, ask questions, and get support throughout your treatment journey.

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Sermorelin Troche

How Sermorelin supports energy and recovery

Sermorelin Troche 600 mcg is a dissolvable troche containing sermorelin, the same peptide offered as an injection. It is supplied as a 90-count for daily use. Sermorelin does not replace your growth hormone. It signals your pituitary gland to produce more of its own, preserving the natural feedback loops your body uses to regulate levels safely over time.

  • Works with your body, not around it

    Unlike synthetic HGH, Sermorelin stimulates your own pituitary to release growth hormone in pulses that follow your natural rhythm. Your body retains control of how much it produces, which is a meaningful difference from synthetic HGH.

  • Sleep, recovery, and lean composition

    Growth hormone is released primarily during deep sleep and plays a central role in tissue repair and lean body maintenance. Many patients notice improved sleep and recovery before other changes become apparent.

  • Provider-guided from start to finish

    A licensed provider reviews your health history, rules out contraindications, sets your starting dose, and monitors your progress. Results build over months and your plan adjusts as you go.

  • Provider-guided from start to finish

    A licensed provider reviews your health history, checks for contraindications, sets an appropriate starting plan, and monitors your progress over time.

  • How to use it

    Clear instructions show you where and how to inject, starting with your very first nightly dose.

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Medura connects you with licensed medical professionals who take the time to review your health history, evaluate your individual needs, and determine which treatments may be right for you.

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Quality and ingredient standards

Made in the U.S.A.

Some treatments are compounded by licensed U.S. pharmacies in facilities registered with the FDA. Registration does not mean a compounded medication is an FDA-approved finished medication.

  • USP <797>

    Sterile compounding standards.

    Documented handling.

    Every batch released to spec.

  • ISO Class 7

    Cleanroom-grade air.

    Filtered environments.

    Tighter contamination control.

Clean ingredients, careful delivery

  • No heavy metals
  • No added dyes
  • Licensed U.S. pharmacies
  • Provider-prescribed
  • Cold-chain protection
  • Plain, unbranded packaging
  • Serves all 50 states
  • HSA and FSA eligible

Medication guide

What to know about Sermorelin Troche

General education to help you prepare for a conversation with a licensed provider. It is not a prescription or personal medical advice.

Generic name
Sermorelin acetate
Brand names
Geref (discontinued)
Drug class
Growth hormone-releasing hormone (GHRH) analog
Form
Troche (600 mcg) dissolved in the mouth
Regulatory status
Compounded, not FDA-approved
FDA-approved use
Previously (Geref): idiopathic growth hormone deficiency in children; diagnostic evaluation of pituitary function.

Sermorelin was FDA-approved (Geref) for growth hormone deficiency in children and for diagnostic testing. The manufacturer discontinued it in 2008; FDA has stated this was not for safety or effectiveness reasons. No FDA-approved sermorelin is currently marketed, so available sermorelin is compounded. Use in adults for wellness or aging is off-label and not established. Sermorelin was never approved as a troche, and absorption of peptides through the lining of the mouth has not been established.

Compounded medications are not FDA-approved. FDA does not review them for safety, effectiveness or quality before they are dispensed. A compounded preparation can differ from approved products in strength, ingredients, dosage form and how it is absorbed, so it should not be assumed to work the same way as an approved medication. Compounding is meant for patients whose needs cannot be met by an FDA-approved drug.

Overview

Sermorelin is used by some providers in adults to stimulate the body’s own growth hormone release. Benefits for aging, body composition or sleep in healthy adults are not established.

Who may be evaluated for it

  • Adults who have discussed the limited evidence with a provider and have no condition that growth hormone could worsen.

Who may not be a good fit

  • People with active cancer or a history of cancer (growth hormone signals can promote cell growth).
  • People with untreated hypothyroidism, or pituitary or hypothalamic disease, need specialist review.
  • People who are pregnant or breastfeeding.

How it works

Sermorelin is a short piece of the brain’s natural GHRH. It signals the pituitary gland to release growth hormone in pulses, which then raises IGF-1, a hormone made mostly by the liver.

Because it works through the pituitary, the body’s normal feedback controls still apply, unlike direct growth hormone injections.

What is still uncertain

Whether raising growth hormone in healthy adults improves health, and what the long-term effects are, is not known.

Potential benefits and realistic timelines

What the evidence supports

  • Sermorelin increases growth hormone release and IGF-1 levels.
  • It increased growth in children with growth hormone deficiency (approved use, now discontinued).

Early or limited research

  • Small studies in older adults reported changes in IGF-1 and some body composition measures.

Not established

  • Anti-aging effects.
  • Meaningful improvements in muscle, fat loss, sleep or energy in healthy adults.
  • Long-term safety in adults.
  1. WeeksIGF-1 levels can rise within a few weeks.
  2. 3 to 6 monthsProviders commonly reassess IGF-1, side effects and how you feel.

Results vary from person to person. Your provider decides whether and how long to continue.

How it’s used

  • Let the troche dissolve fully in the cheek or under the tongue; do not chew or swallow.
  • Usually taken at bedtime on an empty stomach, as directed.

If you miss a dose

Skip it and resume your usual schedule. Do not double up.

Storage and handling

Store as on your pharmacy label; some troches are refrigerated.

Your prescription label and provider instructions always take priority over this general information. Do not change your dose or stop without talking to your provider.

Side effects and safety

More common, usually manageable

  • Mouth irritation
  • Headache
  • Flushing

Less common but serious

  • Allergic reactions
  • Possible effects of raised growth hormone/IGF-1, such as fluid retention, joint pain or changes in blood sugar

Get medical help right away

  • Hives, swelling of the face or throat, or trouble breathing
  • Severe headache with vision changes

Call 911 or go to the nearest emergency room for chest pain, trouble breathing, swelling of the face or throat, fainting, or signs of a stroke (sudden weakness, numbness, trouble speaking or seeing).

Pregnancy, breastfeeding and fertility

Not for use during pregnancy or breastfeeding.

Interactions and combinations

Known interactions

  • Glucocorticoids (steroids) can blunt its effect.
  • Thyroid hormone status affects response.
  • Insulin and diabetes medications: growth hormone can raise blood sugar.

Related treatments and options

Listed for education, not as a recommendation to combine. Any combination needs your provider’s approval.

  • Other growth hormone secretagogues (e.g. ipamorelin, CJC-1295)Avoid

    Not offered by Medura; several are on FDA’s list of substances with safety concerns for compounding.

  • NAD+Evidence insufficient

    Sometimes offered together; no evidence of combined benefit.

Monitoring and follow-up

  • Baseline IGF-1 and, depending on history, blood sugar and thyroid tests.
  • IGF-1 rechecked to keep it in an age-appropriate range.
  • Review of side effects such as swelling or joint pain.

Lab tests and follow-up visits are not included in the medication price unless your plan says so. Your provider will tell you what is needed.

Alternatives to discuss

Potency TestTested
Sterility TestTested
Endotoxin TestTested
pH TestTested

Lab tested medications for quality and potency.

Every medication ships from a licensed U.S. pharmacy in our network, delivered straight to your door.

  • Third party quality control testing

  • Compounded in U.S. pharmacies

Dosage, Schedule & Supply

Dosage
Available strengths include 600 mcg. Your provider selects the strength.
Schedule
Once daily.
Supply
90 or 96 troches, depending on the formulation.
Estimated Supply Duration
Approximately 90 days (90-troche supply) or approximately 96 days (96-troche supply) at one troche daily.

Supply duration is an estimate based on the prescribed treatment plan. Actual duration may vary depending on dosage, frequency of use, and medication expiration.

Treatment information is for educational purposes. Your licensed healthcare provider will determine the appropriate dosage and schedule. Always follow your prescription instructions.

Frequently Asked Questions

Do I need a prescription?

Yes. After your free consultation, a licensed provider reviews your intake and health history to decide whether this treatment is right for you.

How is Sermorelin different from HGH?

Sermorelin stimulates your body to produce its own growth hormone naturally, rather than replacing it with synthetic hormone. Your provider determines whether it is appropriate for you.

How is Sermorelin taken?

Sermorelin is typically a small subcutaneous injection you give yourself at home before bed, timed to work with your body's natural hormone rhythm. Your provider sets your dose and schedule.

How soon will I notice results?

Many patients notice better sleep and recovery in the first weeks. Lean composition and energy changes build over months. Individual results vary.

What are the common side effects?

Effects are usually mild, such as redness, swelling, or itching at the injection site, temporary flushing, mild fluid retention early on, or an occasional headache or dizziness. Your provider reviews the risks with you during your consultation.

What if a provider decides this isn't right for me?

Your consultation is free, and no payment is needed to complete the assessment. If a provider decides this treatment isn't appropriate for you, they will explain why and may suggest other options.

How much does it cost?

The consultation is free and you pay nothing to complete the assessment. If a provider approves treatment, you see the exact monthly price for your plan before you are charged. There are no surprise fees.

Can I use my HSA or FSA?

Yes. Medura accepts HSA and FSA cards at checkout, and we can provide documentation for reimbursement if you need it.

How is it shipped?

Your treatment arrives in plain, unbranded packaging with no pharmacy name on the outside. Temperature-sensitive items ship with cold-chain protection.

What happens after I request treatment through Medura?

You complete an online assessment about your health history, current medications and goals. A licensed provider reviews it and decides whether a prescription is appropriate. Completing the assessment does not guarantee a prescription. If one is written, a licensed pharmacy prepares and ships it, and your provider can adjust or stop treatment as needed. If lab work is needed, your provider will tell you; it may be ordered and billed separately.

What to expect and possible side effects

  1. 1

    Start with a consultation

    A licensed provider reviews your intake, health history, and goals to determine whether Sermorelin is appropriate and what dose fits your body.

  2. 2

    A nightly at-home routine

    Sermorelin is typically administered as a subcutaneous injection before bed, timed to work with your body's natural hormone rhythm.

  3. 3

    What to expect

    Most patients notice improved sleep and recovery in the first weeks. Lean composition and energy changes build over months. Your provider tracks your progress throughout.

Questions to ask your provider

  1. 1.Do I have any history that makes raising growth hormone risky?
  2. 2.What IGF-1 level are we aiming for?
  3. 3.Which form is best for me: injection, nasal or troche?
  4. 4.How will we decide whether to continue?

References

Sources last checked October 17, 2026. This page is for general education and does not replace advice from a licensed provider. Treatment requires a clinical evaluation, and a prescription is written only if a provider decides it is appropriate. Individual results vary.

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