Sexual Health
PT-141
A brain-based peptide for low libido. FDA-approved for women, used off-label in men.
PT-141 (bremelanotide) is a prescription peptide that works directly in the central nervous system to increase sexual desire and arousal. Unlike sildenafil or tadalafil, which work by increasing blood flow, PT-141 activates melanocortin receptors in the brain that are specifically involved in sexual motivation. The result is an increase in desire itself, not just physical response.
Starting at $226.99/month
10% off your first month. Reflects the 1-month intro price.
Free telehealth consultation. Pay only if a provider approves your treatment plan.
Free expedited Rx shipping to all 50 states.
A licensed provider determines the right dose for you.
HSA and FSA accepted.
Compounded in a licensed pharmacy.
Medically reviewed by:Medura Clinical Team
Last updated:July 21, 2026
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Every treatment plan is reviewed by a licensed provider who has time to know your full medical history, not just your symptoms.
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Made in FDA-registered U.S. facilities
Compounded and quality-tested domestically. Discreet packaging. We cover shipping on all plans.
Support that actually listens
Your care team stays with you long after the first shipment. Real check-ins, dose adjustments based on how you actually feel, and honest answers to real questions.
What this is
PT-141 (bremelanotide) is a prescription peptide that works directly in the central nervous system to increase sexual desire and arousal. Unlike sildenafil or tadalafil, which work by increasing blood flow, PT-141 activates melanocortin receptors in the brain that are specifically involved in sexual motivation. The result is an increase in desire itself, not just physical response.
It is FDA-approved under the brand name Vyleesi for premenopausal women diagnosed with hypoactive sexual desire disorder (HSDD), a condition defined by persistently low sexual desire that causes personal distress. It is also used off-label for men who experience low libido that is not addressed by PDE5 inhibitors alone.
PT-141 is taken as a subcutaneous injection 45 minutes to 4 hours before anticipated sexual activity. It does not require daily dosing. A licensed Medura provider reviews your health history and determines the appropriate dose for you.
What to expect
Your treatment timeline, so you know what's coming and when to expect real changes.
- 1
Start with a free consultation
A licensed provider reviews your intake form and health history to determine whether PT-141 is appropriate and what dose fits your needs.
- 2
Use it when you want to
PT-141 is taken as a subcutaneous injection 45 minutes to 4 hours before anticipated sexual activity. You do not need to take it daily. It works on demand.
- 3
Results build with experience
Most patients notice increased desire and arousal within the first few uses. Your provider adjusts your dose based on your response and any side effects.
A different approach to sexual wellness
Most ED and libido treatments work on blood flow or hormones. PT-141 is different. It works on the melanocortin receptors in the central nervous system that are directly involved in sexual arousal and desire.
Works on desire, not just performance
PT-141 activates brain pathways involved in sexual motivation, making it effective for people whose issue is low desire rather than mechanical function. This distinguishes it from PDE5 inhibitors like sildenafil.
Effective for both women and men
PT-141 is FDA-approved for premenopausal women with HSDD and is used off-label in men. It is one of the few treatments for sexual health that has demonstrated effectiveness across genders.
On-demand, not a daily commitment
You take PT-141 only when you want to. There is no daily dosing schedule, and effects typically begin within 45 minutes and can last several hours.
Lab tested medications for quality and potency.
Every medication ships from a licensed U.S. pharmacy in our network, delivered straight to your door.
Third party quality control testing
Compounded in U.S. pharmacies
Safety and eligibility
This treatment is prescription-only. Your eligibility will be determined during your free consultation with a provider based on your full medical history, current medications, and health goals. Nothing on this page guarantees approval.
Generally appropriate for:
- •Adult women experiencing low sexual desire or hypoactive sexual desire disorder
- •Those who have not responded to hormonal interventions
- •Patients without significant cardiovascular conditions
Generally not appropriate if:
- •Patients with uncontrolled hypertension
- •Those taking certain medications that interact with melanocortin agonists
- •Pregnant or breastfeeding individuals
- •Patients with a history of cardiovascular disease without provider clearance
Common side effects:
Nausea (most common, typically temporary)
Flushing or warmth in the face and neck
Headache
Mild increase in blood pressure (monitored during consultation)
Injection site discomfort
Individual results vary. This is not a complete list of potential side effects. Your provider will review all risks during your consultation.
Questions, answered
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